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12th Biology Monthly Test -1 ( Zoology - Molecular Genetics )

St. Britto Hr. Sec. School - Madurai

12th Biology Monthly Test -1 ( Zoology - Molecular Genetics )-Aug 2020

Time : 2.30 Hours

Part - A

Multiple Choice Question - Answer All Question

Meselson and Stahl’s experiment proved
Transduction

Transformation

DNA is the genetic material

Semi-conservative nature of DNA replication
Which of the following statements about DNA replication is not correct?
Unwinding of DNA molecule occurs as hydrogen bonds break.

Replication occurs as each base is paired with another exactly like it

Process is known as semi conservative replication because one old strand is conserved in the new molecule.

Complementary base pairs are held together with hydrogen bonds

When lactose is present in the culture medium:

Transcription of lac y, lac z, lac a genes occurs.
Repressor is unable to bind to the operator.
Repressor is able to bind to the operator.
Both (a) and (b) are correct.

Which of the following is the correct sequence of event with reference to the central dogma?

Transcription, Translation, Replication
Transcription, Replication, Translation
Duplication, Translation, Transcription
Replication, Transcription, Translation

In human beings chromosome ___________ has one height gene density.

18
20
19
22

The distance between two consecutive base pairs in DNA is_________.

3.4 nm
0.34 nm
34.0nm
31x10^-9

The term ___________ refers to DNA of Prokaryotes.

Nuclein
Ribozyme
Genophore
Nucleosome

_______demonstrated that RNA is the genetic material in RNA containing viruses.

Avery
Conrat and Singer
Griffith
Watson and Crick

The Okazaki segments are joined by _________.

DNA polymerase
RNA polymerase
DNA ligase
Endonuclease

The first codon to be deciphered was __ which codes for .

AAA, proline
GGG, alanine
UUU, Phenylalanine
TTT, arginine

The term adapter molecule refers to ________.

mRNA
DNA
rRNA
tRNA

A nucleosome has _________ histone protein molecules.

6
8
10
24

DNA fmger printing technique was developed by

Frederick Sanger
Alex Jeffrey
Hershey
Rosalind Franklin

_________ proposed a model for the nucleosome.

Dupraw
Messelson
Kornberg
Griffith

The experiment conducted by Griffith was based on_________.

Transduction
Replication
Transformation
Conjucation

Part - B

Generic 2 - Answer All Question

What is a nucleosome?

What is base pair rule?

In E.coli, three enzymes β- galactosidase, permease and transacetylase are produced in the presence of lactose. Explain why the enzymes are not synthesized in the absence of lactose.
Differentiate - Template strand and coding strand.

Differentiate - Leading stand and lagging strand

What are nucleotides?

Why is the term nucleic acid used for DNA and RNA?
Mention any two ways in which single nucleotide polymorphism (SNPs) identified in human genome can bring revolutionary change in biological and medical science

What does 'RNA world' refer to?

Give reasons: Genetic code is ‘universal’.

Part - C

Generic 3 - Answer All Question

Distinguish between structural gene, regulatory gene and operator gene

State one gene one enzyme hypothesis

What are okazaki fragments?

Define a operon.

What is S-D Sequence?

Why tRNA is called an adapter molecule?

What is a genetic code?

What are the three structural differences between RNA and DNA?

What is reverse pharmacogenomicst?

Why the human genome project is called a mega project?
A low level of expression of lac operon occurs at all the windows for treatment of various genetic disorders. Justify the statement

Part - D

Generic 5 - Answer All Question

Explain the formation of a nucleosome.
If the coding sequence in a transcription unit is written as follows:
5' TGCATGCATGCATGCATGCATGCATGC 3' Write down the sequence of mRNA

It is established that RNA is the first genetic material. Justify giving reasons.

How is the two stage process of protein synthesis advantageous?

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